Connect Once.
Communicate Everywhere.
Kno2 is a Full-Stack Communication Network purpose-built for providers, connecting clinical systems, data, workflows, and communication pathways — so providers, patients, payers, and healthcare technology platforms all win.
- Improve Data Access
- Reduce Vendor Fragmentation
- Future Proof Communication
Healthcare communication should be simple.
Over time, healthcare communication has become increasingly fragmented as organizations layer on new tools to meet changing interoperability demands.
Many teams end up managing fragmented connections and integrations to share clinical information with other providers, payers, and third parties.
Kno2 replaces that patchwork with one communication network, making it easier to exchange information without adding a new vendor every time something changes.
Kno2 Products
Kno2 provides two simple ways to access its full-stack communication network
Kno2 Communication API
The single integration that unlocks Kno2’s full-stack communication network for provider organizations, payers, EHRs, and health IT companies.
Kno2fy Portal
Kno2’s turnkey, web-based portal that gives any healthcare technology or provider organization immediate access to the Kno2 communication network.
Deliver the right information to the right person at the right time, within the workflows healthcare depends on.
For
EHRs
Help users exchange information reliably without adding a new vendor for every communication need.
For
Health Platforms
Support the data exchange needed to power connected products and workflows.
For
Providers
Reduce friction in clinical and operational workflows with more reliable communication across care settings.
For
Payers
Enable exchange across products, lines of business, and partner networks through one infrastructure.
For Value-Based
Care Organizations
Connect to the information needed to support care coordination across patient populations.
Get Started with Kno2
Kno2 meets you where you are and helps you move toward a more connected approach to healthcare communication.
Step 1:
Assess your setup
We start with what you need today, like fax, Direct messaging, or other requirements.
Step 2:
Connect once
Our team works with you to integrate Kno2 into your existing systems without adding unnecessary complexity.
Step 3:
Expand over time
As your needs change, you can access additional communication channels and networks through the same connection.
Full Stack Communication
Network FAQs
Kno2 is the nation’s largest healthcare communication network and a federally designated Qualified Health Information Network (QHIN) under TEFCA. Through a single Communication API, Kno2 connects electronic health records (EHRs), clinical systems, data, and workflows to the entire healthcare ecosystem.
Kno2 supports every form of clinical information exchange, from fax to FHIR, so organizations of any size can communicate and share patient information securely without managing multiple integrations.
Kno2 is among the first organizations to receive federal QHIN designation under TEFCA. QHIN services are available through Kno2’s Communication API, which provides comprehensive, on-demand access to clinical information from TEFCA, Carequality, and Kno2’s private network.
In 2025, Kno2 was among the original networks to pledge to the CMS Aligned Networks initiative. As the ecosystem evolves, Kno2 continues to build out these capabilities and make them available through its Communication API.
Kno2 supports communication across fax, Direct Secure Messaging, FHIR, and HL7. As a QHIN enabling TEFCA participation and a Carequality implementor, Kno2 also provides access to national networks through a single integration. The goal is to help organizations communicate across healthcare without managing a separate vendor or connection for every channel.
No. That is the core advantage of Kno2’s Communication API and its Send, Receive, and Find routes. Once you are connected, you are enabled for all communication and clinical information exchange across the ecosystem, you do not need to build to each connection type.
Kno2 handles the heavy lift of connectivity so partners can focus on Kno2 Connected workflows and the best user experience in their own product.
Yes. Kno2 is designed to plug into any EHR or health IT platform through its Communication API and its Communication Portal, Kno2fy. Organizations can support communication without replacing the systems they already rely on.
The goal is to make clinical information exchange easier to manage within existing workflows.
Yes. As the nation’s largest healthcare communication network and a federally designated QHIN, Kno2 holds to the highest level of security and privacy requirements, including R2 HITRUST certification, which it maintains annually.
Kno2 Blog
Why Your Interoperability Strategy Is Missing 80% of Care In the US, the vast
By Travis White, Sr Vice President of Solutions Strategy and Network Growth Information
In behavioral health and substance abuse centers across America, patient information is stuck. According
Testimonials
Kno2 Testimonials
Connected care depends on connected communication.
See how Kno2 helps healthcare organizations reduce fragmentation, improve data access, and support communication at scale.